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  4. Systematic and comprehensive automated ventricle segmentation on ventricle images of the elderly patients: A retrospective study
 
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Systematic and comprehensive automated ventricle segmentation on ventricle images of the elderly patients: A retrospective study
File(s)
fnagi-12-618538.pdf (1.24 MB)
Published version
Author(s)
Zhou, Xi
Ye, Qinghao
Jiang, Yinghui
Wang, Minhao
Niu, Zhangming
more
Type
Journal Article
Abstract
Background and Objective: Ventricle volume is closely related to hydrocephalus, brain atrophy, Alzheimer's, Parkinson's syndrome, and other diseases. To accurately measure the volume of the ventricles for elderly patients, we use deep learning to establish a systematic and comprehensive automated ventricle segmentation framework.

Methods: The study participation included 20 normal elderly people, 20 patients with cerebral atrophy, 64 patients with normal pressure hydrocephalus, and 51 patients with acquired hydrocephalus. Second, get their imaging data through the picture archiving and communication systems (PACS) system. Then use ITK software to manually label participants' ventricular structures. Finally, extract imaging features through machine learning.

Results: This automated ventricle segmentation method can be applied not only to CT and MRI images but also to images with different scan slice thicknesses. More importantly, it produces excellent segmentation results (Dice > 0.9).

Conclusion: This automated ventricle segmentation method has wide applicability and clinical practicability. It can help clinicians find early disease, diagnose disease, understand the patient's disease progression, and evaluate the patient's treatment effect.
Date Issued
2020-12
Date Acceptance
2020-11-23
Citation
Frontiers in Aging Neuroscience, 2020, 12
URI
http://hdl.handle.net/10044/1/84927
DOI
https://www.dx.doi.org/10.3389/fnagi.2020.618538
ISSN
1663-4365
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Aging Neuroscience
Volume
12
Copyright Statement
© 2020 Zhou, Ye, Jiang, Wang, Niu, Menpes-Smith, Fang, Liu, Xia and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY, https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
https://creativecommons.org/licenses/by/4.0/
Sponsor
European Research Council Horizon 2020
Commission of the European Communities
Innovative Medicines Initiative
Grant Number
H2020-SC1-FA-DTS-2019-1 952172
101005122
101005122
Subjects
0601 Biochemistry and Cell Biology
1109 Neurosciences
1702 Cognitive Sciences
Publication Status
Published
Article Number
618538
Date Publish Online
2020-12-16
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