Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment
Author(s)
Rane, Swapnil
Rana, Seema
Mudrabettu, Chetan
Jha, Vivekananda
Joshi, Kusum
Type
Journal Article
Abstract
Heavy-chain deposition disease (HCDD) is the least common of the monoclonal immunoglobulin deposition diseases with only 24 reported cases in English literature, including the present case. The rarity of this disease merits its documentation. We present a case of HCDD from our archival material, who presented with rapidly progressive renal failure and nephrotic syndrome and was found to have nodular glomerulosclerosis on renal biopsy which on immunofluorescence and electron microscopy confirmed HCDD of immunoglobulin G1 type without any light-chain deposition. We also present an in-depth literature review on HCDD.
Date Issued
2012-10-01
Date Acceptance
2012-04-26
Citation
Clinical Kidney Journal, 2012, 5 (5), pp.383-389
ISSN
2048-8505
Publisher
European Renal Association - European Dialysis and Transplant Association (ERA-EDTA)
Start Page
383
End Page
389
Journal / Book Title
Clinical Kidney Journal
Volume
5
Issue
5
Copyright Statement
© The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/26019812
PII: sfs062
Subjects
monoclonal immunoglobulin deposition disease
nodular glomerulosclerosis
rapidly progressive renal failure
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2012-10-01