Putting the brakes on inhibitory models of frontal lobe function
File(s)HampshireNeuroImage2015.pdf (2.04 MB)
Published version
Author(s)
Hampshire, A
Type
Journal Article
Abstract
There has been much recent debate regarding the neural basis of motor response inhibition. An influential hypothesis from the last decade proposes that a module within the right inferior frontal cortex (RIFC) of the human brain is dedicated to supporting response inhibition. However, there is growing evidence to support the alternative view that response inhibition is just one prominent example of the many cognitive control processes that are supported by the same set of 'domain general' functional networks. Here, I test directly between the modular and network accounts of motor response inhibition by applying a combination of data-driven, event-related and functional connectivity analyses to fMRI data from a variety of attention and inhibition tasks. The results demonstrate that there is no inhibitory module within the RIFC. Instead, response inhibition recruits a functionally heterogeneous ensemble of RIFC networks, which can be dissociated from each other in the context of other task demands.
Date Issued
2015-03-25
Date Acceptance
2015-03-19
Citation
Neuroimage, 2015, 113, pp.340-355
ISSN
1095-9572
Publisher
Elsevier
Start Page
340
End Page
355
Journal / Book Title
Neuroimage
Volume
113
Copyright Statement
© 2015 The Author. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).
(http://creativecommons.org/licenses/by-nc-nd/4.0/).
Publication Status
Published