Engineering Yarrowia lipolytica to produce fuels and chemicals from xylose: A review.
Author(s)
Sun, Tao
Yu, Yizi
Wang, Kaifeng
Ledesma-Amaro, Rodrigo
Ji, Xiao-Jun
Type
Journal Article
Abstract
The production of chemicals and fuels from lignocellulosic biomass has great potential industrial applications due to its economic feasibility and environmental attractiveness. However, the utilized microorganisms must be able to use all the sugars present in lignocellulosic hydrolysates, especially xylose, the second most plentiful monosaccharide on earth. Yarrowia lipolytica is a good candidate for producing various valuable products from biomass, but this yeast is unable to catabolize xylose efficiently. The development of metabolic engineering facilitated the application of Y. lipolytica as a platform for the bioconversion of xylose into various value-added products. Here, we reviewed the research progress on natural xylose-utilization pathways and their reconstruction in Y. lipolytica. The progress and emerging trends in metabolic engineering of Y. lipolytica for producing chemicals and fuels are further introduced. Finally, challenges and future perspectives of using lignocellulosic hydrolysate as substrate for Y. lipolytica are discussed.
Date Issued
2021-10
Date Acceptance
2021-06-28
Citation
Bioresource Technology, 2021, 337, pp.1-8
ISSN
0960-8524
Publisher
Elsevier
Start Page
1
End Page
8
Journal / Book Title
Bioresource Technology
Volume
337
Copyright Statement
© 2021 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
The Royal Society
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/34320765
PII: S0960-8524(21)00824-5
Grant Number
NAF\R1\201187
Subjects
Chemicals
Fuels
Metabolic engineering
Xylose
Yarrowia lipolytica
Biomass
Metabolic Engineering
Xylose
Yarrowia
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2021-07-03