Progesterone-related immune modulation of pregnancy and labor
File(s)
Published version
Author(s)
Shah, Nishel M
Lai, Pei F
Imami, Nesrina
Johnson, Mark R
Type
Journal Article
Abstract
Pregnancy involves a complex interplay between maternal neuroendocrine and immunological systems in order to establish and sustain a growing fetus. It is thought that the uterus at pregnancy transitions from quiescent to laboring state in response to interactions between maternal and fetal systems at least partly via altered neuroendocrine signaling. Progesterone (P4) is a vital hormone in maternal reproductive tissues and immune cells during pregnancy. As such, P4 is widely used in clinical interventions to improve the chance of embryo implantation, as well as reduce the risk of miscarriage and premature labor. Here we review research to date that focus on the pathways through which P4 mediates its actions on both the maternal reproductive and immune system. We will dissect the role of P4 as a modulator of inflammation, both systemic and intrinsic to the uterus, during human pregnancy and labor.
Date Issued
2019-03-29
Date Acceptance
2019-03-11
Citation
Frontiers in Endocrinology, 2019, 10
ISSN
1664-2392
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Endocrinology
Volume
10
Copyright Statement
© 2019 Shah, Lai, Imami and Johnson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY - https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Publication Status
Published
Article Number
198
Date Publish Online
2019-03-29