Regioselective electrochemical cyclobutanol ring expansion to 1-tetralones
File(s)
Published version
Author(s)
Petti, Alessia
Natho, Philipp
Lam, Kevin
Parsons, Philip
Type
Journal Article
Abstract
A mild electrochemical method for the regioselective preparation of 1‐tetralones under environmentally friendly conditions from readily available cyclobutanols was developed. A series of aromatic‐ and heteroaromatic‐fused 1‐tetralones was accessed through ring expansion of the functionalized cyclobutanols via electrochemical generation of alkoxy radicals and intramolecular cyclization.
Date Issued
2021-02-05
Date Acceptance
2020-12-13
Citation
European Journal of Organic Chemistry, 2021, 2021 (5), pp.854-858
ISSN
1099-0690
Publisher
Wiley
Start Page
854
End Page
858
Journal / Book Title
European Journal of Organic Chemistry
Volume
2021
Issue
5
Copyright Statement
© 2020 The Authors. European Journal of Organic Chemistry published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Subjects
Science & Technology
Physical Sciences
Chemistry, Organic
Chemistry
Cyclobutanols
Electrocatalysis
Ring expansion
Synthetic methods
Tetralones
ORGANIC ELECTROSYNTHESIS
TERT-CYCLOBUTANOLS
DIVERSITY
CATALYSIS
0304 Medicinal and Biomolecular Chemistry
0305 Organic Chemistry
Organic Chemistry
Publication Status
Published
Date Publish Online
2020-12-16