Clusters of SARS-CoV-2 lineage B.1.1.7 infection after vaccination with adenovirus-vectored and inactivated vaccines
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
A SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination. On March 2021, we detected SARS-CoV-2 RNA in nasopharyngeal samples from 14 of 22 individuals vaccinated with a single-dose of ChAdOx1 (outbreak A, n = 26), and 22 of 42 of individuals with two doses of the CoronaVac vaccine (outbreak B, n = 52) for breakthrough infection rates for ChAdOx1 of 63.6% and 52.4% for CoronaVac. The outbreaks were caused by two independent clusters of the B.1.1.7 VOC. The serum of PCR-positive symptomatic SARS-CoV-2-infected individuals had ~1.8–3.4-fold more neutralizing capacity against B.1.1.7 compared to the serum of asymptomatic individuals. These data based on exploratory analysis suggest that the B.1.1.7 variant can infect individuals partially immunized with a single dose of an adenovirus-vectored vaccine or fully immunized with two doses of an inactivated vaccine, although the vaccines were able to reduce the risk of severe disease and death caused by this VOC, even in the elderly.
Date Issued
2021-11-01
Date Acceptance
2021-10-15
Citation
Viruses, 2021, 13 (11)
ISSN
1999-4915
Publisher
MDPI AG
Journal / Book Title
Viruses
Volume
13
Issue
11
Copyright Statement
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/34834934
PII: v13112127
Subjects
B.1.1.7 & nbsp;
COVID-19 & nbsp;
Life Sciences & Biomedicine
outbreak & nbsp;
SARS-CoV-2 & nbsp;
Science & Technology
vaccine & nbsp;
variant of concern & nbsp;
Virology
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
2127
Date Publish Online
2021-10-22