Activity dependent downscaling of subthreshold synaptic inputs during slow wave sleep like activity in vivo
File(s)
Published version
Author(s)
González Rueda, Ana
Pedrosa, Victor
Feord, Rachael
Clopath, C
Paulsen, Ole
Type
Journal Article
Abstract
Activity-dependent synaptic plasticity is critical for cortical circuit refinement. The synaptic homeostasis hypothesis suggests that synaptic connections are strengthened during wake and downscaled during sleep; however, it is not obvious how the same plasticity rules could explain both outcomes. Using whole-cell recordings and optogenetic stimulation of presynaptic input in urethane-anesthetized mice, which exhibit slow-wave-sleep (SWS)-like activity, we show that synaptic plasticity rules are gated by cortical dynamics in vivo. While Down states support conventional spike timing-dependent plasticity, Up states are biased toward depression such that presynaptic stimulation alone leads to synaptic depression, while connections contributing to postsynaptic spiking are protected against this synaptic weakening. We find that this novel activity-dependent and input-specific downscaling mechanism has two important computational advantages: (1) improved signal-to-noise ratio, and (2) preservation of previously stored information. Thus, these synaptic plasticity rules provide an attractive mechanism for SWS-related synaptic downscaling and circuit refinement.
Date Issued
2018-03-21
Date Acceptance
2018-01-10
Citation
Neuron, 2018, 97 (6), pp.1244-1252.e5
ISSN
0896-6273
Publisher
Elsevier
Start Page
1244
End Page
1252.e5
Journal / Book Title
Neuron
Volume
97
Issue
6
Copyright Statement
© 2018 The Author(s). Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Sponsor
Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Grant Number
200790/Z/16/Z
BB/P018785/1
ORCA 64155 (BB/N013956/1)
Subjects
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
RAT BARREL CORTEX
SOMATOSENSORY CORTEX
CELL-TYPE
PLASTICITY
DEPRESSION
NEURONS
POTENTIATION
SPIKING
ELECTROENCEPHALOGRAM
HOMEOSTASIS
LTD
LTP
STDP
Up-Down state
in vivo
mouse
network oscillations
sleep
somatosensory cortex
1109 Neurosciences
1702 Cognitive Science
Neurology & Neurosurgery
Publication Status
Published
Date Publish Online
2018-03-01