Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Sepsis is a major growing global burden and a major challenge to intensive care clinicians, researchers, guideline committee members and policy makers, because of its high and increasing incidence and great pathophysiological, molecular, genetic and clinical complexity. In spite of recent progress, short-term mortality remains high and there is growing evidence of long-term morbidity and increased long-term mortality in survivors of sepsis both in developed and developing countries. Further improvement in the care of patients with sepsis will impact upon global health. In this narrative review, invited experts describe the expected challenges and progress to be made in the near future. We focus on diagnosis, resuscitation (fluids, vasopressors, inotropes, blood transfusion and hemodynamic targets) and infection (antibiotics and infection biomarkers), as these areas are key, if initial management and subsequent outcomes are to be improved in patients with sepsis.
Date Issued
2016-10-01
Date Acceptance
2016-09-25
Citation
Intensive Care Medicine, 2016, 42 (12), pp.1958-1969
ISSN
1432-1238
Publisher
Springer Verlag (Germany)
Start Page
1958
End Page
1969
Journal / Book Title
Intensive Care Medicine
Volume
42
Issue
12
Copyright Statement
© Springer-Verlag Berlin Heidelberg and ESICM 2016. The final publication is available at Springer via http://dx.doi.org/10.1007/s00134-016-4577-z
Subjects
Antibiotic
Critical care
Intensive care
Sepsis
Shock
Emergency & Critical Care Medicine
1103 Clinical Sciences
1117 Public Health And Health Services
Publication Status
Published