Quasi-robust control of biochemical reaction networks via stochastic morphing.
File(s)rsif.2020.0985.pdf (2.34 MB)
Published version
Author(s)
Plesa, Tomislav
Stan, Guy-Bart
Ouldridge, Thomas E
Bae, Wooli
Type
Journal Article
Abstract
One of the main objectives of synthetic biology is the development of molecular controllers that can manipulate the dynamics of a given biochemical network that is at most partially known. When integrated into smaller compartments, such as living or synthetic cells, controllers have to be calibrated to factor in the intrinsic noise. In this context, biochemical controllers put forward in the literature have focused on manipulating the mean (first moment) and reducing the variance (second moment) of the target molecular species. However, many critical biochemical processes are realized via higher-order moments, particularly the number and configuration of the probability distribution modes (maxima). To bridge the gap, we put forward the stochastic morpher controller that can, under suitable timescale separations, morph the probability distribution of the target molecular species into a predefined form. The morphing can be performed at a lower-resolution, allowing one to achieve desired multi-modality/multi-stability, and at a higher-resolution, allowing one to achieve arbitrary probability distributions. Properties of the controller, such as robustness and convergence, are rigorously established, and demonstrated on various examples. Also proposed is a blueprint for an experimental implementation of stochastic morpher.
Date Issued
2021-04-14
Date Acceptance
2021-03-18
Citation
Journal of the Royal Society Interface, 2021, 18 (177), pp.1-14
ISSN
1742-5662
Publisher
The Royal Society
Start Page
1
End Page
14
Journal / Book Title
Journal of the Royal Society Interface
Volume
18
Issue
177
Copyright Statement
© 2021 The Authors.
Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
License URL
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Royal Academy Of Engineering
The Royal Society
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33849334
Grant Number
EP/M002187/1
EP/P02596X/1
CiET1819\5
UF150067
Subjects
DNA computing
control
robustness
stochastic biochemical reaction networks
synthetic biology
timescale separation
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2021-04-14