Biosilicate (R)-gelatine bone scaffolds by the foam replica technique: development and characterization
Author(s)
Type
Journal Article
Abstract
The development of bioactive glass-ceramic materials has been a topic of great interest aiming at enhancing the mechanical strength of traditional bioactive scaffolds. In the present study, we test and demonstrate the use of Biosilicate® glass-ceramic powder to fabricate bone scaffolds by the foam replica method. Scaffolds possessing the main requirements for use in bone tissue engineering (95% porosity, 200–500 μm pore size) were successfully produced. Gelatine coating was investigated as a simple approach to increase the mechanical competence of the scaffolds. The gelatine coating did not affect the interconnectivity of the pores and did not significantly affect the bioactivity of the Biosilicate® scaffold. The gelatine coating significantly improved the compressive strength (i.e. 0.80 ± 0.05 MPa of coated versus 0.06 ± 0.01 MPa of uncoated scaffolds) of the Biosilicate® scaffold. The combination of Biosilicate® glass-ceramic and gelatine is attractive for producing novel scaffolds for bone tissue engineering.
Date Issued
2013-08-13
Date Acceptance
2013-07-11
Citation
Science and Technology of Advanced Materials, 2013, 14 (4)
ISSN
1468-6996
Publisher
Institute of Physics, National Institute for Materials Science
Journal / Book Title
Science and Technology of Advanced Materials
Volume
14
Issue
4
Copyright Statement
© 2013 National Institute for Materials Science. C
ontent from this work may be used under the terms of the
Creative Commons Attribution-NonCommercial-ShareAlike
3.0 licence
. Any further distribution of this work must maintain attribution to
the author(s) and the title of the work, journal citation and DOI.
ontent from this work may be used under the terms of the
Creative Commons Attribution-NonCommercial-ShareAlike
3.0 licence
. Any further distribution of this work must maintain attribution to
the author(s) and the title of the work, journal citation and DOI.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000323882000019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Technology
Materials Science, Multidisciplinary
Materials Science
MATERIALS SCIENCE, MULTIDISCIPLINARY
bioactivity
glass-ceramics
scaffolds
bone tissue engineering
GLASS-CERAMIC SCAFFOLDS
POROUS HYDROXYAPATITE CERAMICS
BIOACTIVE GLASS
TISSUE
STRENGTH
GELATIN
COMPOSITES
COATINGS
Publication Status
Published
Article Number
ARTN 045008