TBK1 directs WIPI2 against Salmonella
File(s)
Published version
Author(s)
Boyle, Keith B
Thurston, Teresa LM
Randow, Felix
Type
Journal Article
Abstract
Defense of the mammalian cell cytosol against Salmonella invasion is reliant upon capture of the infiltrating bacteria by macroautophagy (hereafter autophagy), a process controlled by the kinase TBK1. In our recent study we showed that recruitment of TBK1 activity to Salmonella stabilizes the key autophagy regulator WIPI2 on those bacteria, a novel and essential function for TBK1 in the control of the early steps of antibacterial autophagy. Substantial redundancy exists in the precise recruitment mechanism for TBK1 because engagement with any of several Salmonella-associated ‘eat-me’ signals, including host-derived glycans, and K48- and K63-linked ubiquitin chains, suffices to recruit TBK1 functionality. We therefore propose that buffering TBK1 recruitment against potential bacterial interference might be of evolutionary advantage to the host.
Date Issued
2016-11-03
Date Acceptance
2016-09-07
Citation
Autophagy, 2016, 12 (12), pp.2508-2509
ISSN
1554-8627
Publisher
Taylor & Francis
Start Page
2508
End Page
2509
Journal / Book Title
Autophagy
Volume
12
Issue
12
Copyright Statement
© 2016 MRC Laboratory of Molecular Biology. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000390691600023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell Biology
antibacterial autophagy
NDP52
optineurin
PI(3)P
Salmonella
TBK1
WIPI
Publication Status
Published
Date Publish Online
2016-10-18