Nonparametric density flows for MRI intensity normalisation
File(s)castro2018miccai.pdf (1.26 MB)
Accepted version
Author(s)
Castro, DC
Glocker, B
Type
Conference Paper
Abstract
With the adoption of powerful machine learning methods in medical image analysis, it is becoming increasingly desirable to aggregate data that is acquired across multiple sites. However, the underlying assumption of many analysis techniques that corresponding tissues have consistent intensities in all images is often violated in multi-centre databases. We introduce a novel intensity normalisation scheme based on density matching, wherein the histograms are modelled as Dirichlet process Gaussian mixtures. The source mixture model is transformed to minimise its L2 divergence towards a target model, then the voxel intensities are transported through a mass-conserving flow to maintain agreement with the moving density. In a multi-centre study with brain MRI data, we show that the proposed technique produces excellent correspondence between the matched densities and histograms. We further demonstrate that our method makes tissue intensity statistics substantially more compatible between images than a baseline affine transformation and is comparable to state-of-the-art while providing considerably smoother transformations. Finally, we validate that nonlinear intensity normalisation is a step toward effective imaging data harmonisation.
Date Issued
2018-09-16
Date Acceptance
2018-05-25
Citation
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2018, 2018, 11070 LNCS, pp.206-214
ISBN
9783030009281
ISSN
0302-9743
Publisher
Springer, Cham
Start Page
206
End Page
214
Journal / Book Title
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2018
Volume
11070 LNCS
Copyright Statement
© Springer Nature Switzerland AG 2018. The final publication is available at Springer via https://doi.org/10.1007/978-3-030-00928-1_24
Sponsor
Commission of the European Communities
Identifier
http://arxiv.org/abs/1806.02613
Grant Number
H2020 - 757173
Source
International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI)
Subjects
Science & Technology
Technology
Computer Science, Theory & Methods
Imaging Science & Photographic Technology
Computer Science
cs.CV
cs.CV
Artificial Intelligence & Image Processing
Publication Status
Published
Start Date
2018-09-16
Finish Date
2018-09-20
Coverage Spatial
Granada, Spain
Date Publish Online
2018-09-26