Review: Neuroprotective nanocarriers in glaucoma
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Glaucoma stands as a primary cause of irreversible blindness globally, characterized by the progressive dysfunction and loss of retinal ganglion cells (RGCs). While current treatments primarily focus on controlling intraocular pressure (IOP), many patients continue to experience vision loss. Therefore, the research focus has shifted to therapeutic targets aimed at preventing or delaying RGC death and optic nerve degeneration to slow or halt disease progression. Traditional ocular drug administration, such as eye drops or oral medications, face significant challenges due to the eye’s unique structural and physiological barriers, which limit effective drug delivery. Invasive methods like intravitreal injections can cause side effects such as bleeding, inflammation, and infection, making non-invasive delivery methods with high bioavailability very desirable. Nanotechnology presents a promising approach to addressing these limitations in glaucoma treatment. This review summarizes current approaches involving neuroprotective drugs combined with nanocarriers, and their impact for future use.
Date Issued
2024-09-10
Date Acceptance
2024-09-06
Citation
Pharmaceuticals, 2024, 17 (9)
ISSN
1424-8247
Publisher
MDPI AG
Journal / Book Title
Pharmaceuticals
Volume
17
Issue
9
Copyright Statement
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39338350
PII: ph17091190
Subjects
Chemistry, Medicinal
DELIVERY
EYE
glaucoma
HUMAN SERUM-ALBUMIN
IN-VITRO
Life Sciences & Biomedicine
MODEL
nanocarriers
nanomedicine
NANOPARTICLES
neuroprotection
neuroprotective
NEUROTROPHIC FACTOR
ocular neurodegenerative disease
OPEN-ANGLE GLAUCOMA
OPTIC-NERVE HEAD
Pharmacology & Pharmacy
retinal ganglion cell
RETINAL GANGLION-CELLS
Science & Technology
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
1190
Date Publish Online
2024-09-10