Recent electrochemical advancements for liquid-biopsy nucleic acid detection for point-of-care prostate cancer diagnostics and prognostics
File(s)
Published version
Author(s)
Broomfield, Joseph
Kalofonou, Melpomeni
Bevan, Charlotte L
Georgiou, Pantelis
Type
Journal Article
Abstract
Current diagnostic and prognostic tests for prostate cancer require specialised laboratories and have low specificity for prostate cancer detection. As such, recent advancements in electrochemical devices for point of care (PoC) prostate cancer detection have seen significant interest. Liquid-biopsy detection of relevant circulating and exosomal nucleic acid markers presents the potential for minimally invasive testing. In combination, electrochemical devices and circulating DNA and RNA detection present an innovative approach for novel prostate cancer diagnostics, potentially directly within the clinic. Recent research in electrochemical impedance spectroscopy, voltammetry, chronoamperometry and potentiometric sensing using field-effect transistors will be discussed. Evaluation of the PoC relevance of these techniques and their fulfilment of the WHO’s REASSURED criteria for medical diagnostics is described. Further areas for exploration within electrochemical PoC testing and progression to clinical implementation for prostate cancer are assessed.
Date Issued
2024-09-01
Date Acceptance
2024-09-10
Citation
Biosensors, 2024, 14 (9)
ISSN
2079-6374
Publisher
MDPI
Journal / Book Title
Biosensors
Volume
14
Issue
9
Copyright Statement
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39329818
PII: bios14090443
Subjects
ABIRATERONE
Chemistry
Chemistry, Analytical
chronoamperometry
CIRCULATING TUMOR-CELLS
CLINICAL-SIGNIFICANCE
EIS
electrochemical devices
ENZALUTAMIDE
field-effect transistors
Instruments & Instrumentation
ISFET
MEN
MESSENGER-RNA
MICRORNAS
MIRNA
MOLECULAR URINE TEST
Nanoscience & Nanotechnology
nucleic acids
Physical Sciences
point of care
prostate cancer
Science & Technology
Science & Technology - Other Topics
Technology
VALIDATION
voltammetry
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
443
Date Publish Online
2024-09-14