Stratification of sepsis patients on admission into the intensive care unit according to differential plasma metabolic phenotypes
Author(s)
Type
Journal Article
Abstract
Delayed diagnosis of patients with sepsis or septic shock is associated with increased mortality and morbidity. UPLC-MS and NMR spectroscopy were used to measure panels of lipoproteins, lipids, biogenic amines, amino acids, and tryptophan pathway metabolites in blood plasma samples collected from 152 patients within 48 h of admission into the Intensive Care Unit (ICU) where 62 patients had no sepsis, 71 patients had sepsis, and 19 patients had septic shock. Patients with sepsis or septic shock had higher concentrations of neopterin and lower levels of HDL cholesterol and phospholipid particles in comparison to nonsepsis patients. Septic shock could be differentiated from sepsis patients based on different concentrations of 10 lipids, including significantly lower concentrations of five phosphatidylcholine species, three cholesterol esters, one dihydroceramide, and one phosphatidylethanolamine. The Supramolecular Phospholipid Composite (SPC) was reduced in all ICU patients, while the composite markers of acute phase glycoproteins were increased in the sepsis and septic shock patients within 48 h admission into ICU. We show that the plasma metabolic phenotype obtained within 48 h of ICU admission is diagnostic for the presence of sepsis and that septic shock can be differentiated from sepsis based on the lipid profile.
Date Issued
2024-04-05
Date Acceptance
2024-03-07
Citation
Journal of Proteome Research, 2024, 23 (4), pp.1328-1340
ISSN
1535-3893
Publisher
American Chemical Society
Start Page
1328
End Page
1340
Journal / Book Title
Journal of Proteome Research
Volume
23
Issue
4
Copyright Statement
Copyright © 2024 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY-NC-ND 4.0 .
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/38513133
Subjects
APACHE
Biochemical Research Methods
Biochemistry & Molecular Biology
BIOMARKER
CHOLESTEROL
diagnostic modeling
GLYCA
HIGH-DENSITY-LIPOPROTEIN
ICU
Life Sciences & Biomedicine
lipids
lipoproteins
mass spectrometry
metabolic phenotyping
NEOPTERIN
NMR spectroscopy
pharmaco-metabonomics
plasmaIVDr
PROTON NMR-SPECTROSCOPY
RECOVERY
RISK
SARS-COV-2 INFECTION
Science & Technology
sepsis
septic shock
SERUM
SPC
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2024-03-21