Memory consolidation in aging and MCI after 1 Week
Author(s)
Type
Journal Article
Abstract
Objective: To assess consolidation in amnestic mild cognitive impairment (aMCI), controlling for differences in initial learning and using a protracted delay period for recall. Method: 15 individuals with aMCI were compared with 15 healthy older adult controls on a story learning task. Subjects were trained to criteria to equalize initial learning across subjects. Recall was tested at both the 30-min typically used delay and a 1-week delay used to target consolidation. Results: Using repeated measures ANOVAs adjusted for age, we found group × time point interactions across the entire task between the final trial and 30-min delay, and again between the 30-min and 1-week delay periods, with aMCI having greater declines in recall as compared with controls. Significant group main effects were also found, with aMCI recalling less than controls. Conclusion: Consolidation was impaired in aMCI as compared with controls. Our findings indicate that aMCI-related performance typically measured at 30 min underestimates aMCI-associated memory deficits. This is the first study to isolate consolidation by controlling for initial learning differences and using a protracted delay period to target consolidation in an aMCI sample. (PsycInfo Database Record (c) 2020 APA, all rights reserved)
Date Issued
2014-03-01
Date Acceptance
2013-11-01
Citation
Neuropsychology, 2014, 28 (2), pp.273-280
ISSN
0894-4105
Publisher
American Psychological Association
Start Page
273
End Page
280
Journal / Book Title
Neuropsychology
Volume
28
Issue
2
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000332342100012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Social Sciences
Science & Technology
Life Sciences & Biomedicine
Psychology, Clinical
Neurosciences
Psychology
Neurosciences & Neurology
consolidation
episodic learning
amnestic mild cognitive impairment
memory
cognitive aging
MILD-COGNITIVE-IMPAIRMENT
MEDIAL TEMPORAL-LOBE
LONG-TERM-MEMORY
REMOTE AUTOBIOGRAPHICAL MEMORIES
EARLY ALZHEIMERS-DISEASE
TIME-LIMITED ROLE
RETROGRADE-AMNESIA
HIPPOCAMPAL COMPLEX
FUNCTIONAL CONNECTIVITY
PROTEIN-SYNTHESIS
Publication Status
Published
Date Publish Online
2013-11-11