Measurement of eosinophil kinetics In vivo
File(s)
Author(s)
Type
Journal Article
Abstract
Radiolabeled leukocyte scans are used in nuclear medicine to detect sites of infection and inflammation. We have previously demonstrated the use of clinical grade immunomagnetic beads to isolate autologous eosinophils and image their distribution in healthy volunteers. Here we describe the use of radiolabeled eosinophils coupled to single-photon emission computed tomography (SPECT) to quantify eosinophil uptake in the lungs of healthy volunteers, patients with asthma, and patients with focal eosinophilic inflammation.
Date Issued
2021-01-24
Date Acceptance
2020-09-14
Citation
Methods in Molecular Biology, 2021, 2241, pp.183-191
ISSN
1064-3745
Publisher
Humana Press
Start Page
183
End Page
191
Journal / Book Title
Methods in Molecular Biology
Volume
2241
Copyright Statement
© Springer Science+Business Media, LLC, part of Springer Nature 2021. The final publication is available at Springer via https://link.springer.com/protocol/10.1007%2F978-1-0716-1095-4_15
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33486737
Subjects
Cell trafficking
Eosinophils
Granulocytes
Imaging
Radiolabeling
SPECT
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2021-01-24