Elevated 18:0 lysophosphatidylcholine contributes to the development of pain in tissue injury
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Tissue injuries, including burns, are major causes of death and morbidity worldwide. These injuries result in the release of intracellular molecules and subsequent inflammatory reactions, changing the tissues’ chemical milieu and leading to the development of persistent pain through activating pain-sensing primary sensory neurons. However, the majority of pain-inducing agents in injured tissues are unknown. Here, we report that, amongst other important metabolite changes, lysophosphatidylcholines (LPCs) including 18:0 LPC exhibit significant and consistent local burn injury-induced changes in concentration. 18:0 LPC induces immediate pain and the development of hypersensitivities to mechanical and heat stimuli through molecules including the transient receptor potential ion channel, vanilloid sub-family, member 1 and member 2 at least partly via increasing lateral pressure in the membrane. As levels of LPCs including 18:0 LPC increase in other tissue injuries, our data reveal a novel role for these lipids in injury-associated pain. These findings have high potential to improve patient care.
Date Issued
2023-02-01
Date Acceptance
2022-05-27
Citation
Pain, 2023, 164 (2), pp.e103-e115
ISSN
0304-3959
Publisher
Lippincott, Williams & Wilkins
Start Page
e103
End Page
e115
Journal / Book Title
Pain
Volume
164
Issue
2
Copyright Statement
© 2022 The Author(s). This is an open access article distributed under the Creative Commons Attribution
License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited
License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited
License URL
Identifier
https://journals.lww.com/pain/Abstract/9900/Elevated_18_0_lysophosphatidylcholine_contributes.114.aspx
Publication Status
Published
Date Publish Online
2022-06-07