Circulating non-coding RNAS as indicators of fibrosis and heart failure severity
File(s)
Published version
Author(s)
Boichenko, Veronika
Noakes, Victoria Maria
Reilly-O'Donnell, Benedict
Luciani, Giovanni Battista
Emanueli, Costanza
Type
Journal Article
Abstract
Heart failure (HF) is a leading cause of morbidity and mortality worldwide, representing a complex clinical syndrome in which the heart’s ability to pump blood efficiently is impaired. HF can be subclassified into heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), each with distinct pathophysiological mechanisms and varying levels of severity. The progression of HF is significantly driven by cardiac fibrosis, a pathological process in which the extracellular matrix undergoes abnormal and uncontrolled remodelling. Cardiac fibrosis is characterized by excessive matrix protein deposition and the activation of myofibroblasts, increasing the stiffness of the heart, thus disrupting its normal structure and function and promoting lethal arrythmia. MicroRNAs, long non-coding RNAs, and circular RNAs, collectively known as non-coding RNAs (ncRNAs), have recently gained significant attention due to a growing body of evidence suggesting their involvement in cardiac remodelling such as fibrosis. ncRNAs can be found in the peripheral blood, indicating their potential as biomarkers for assessing HF severity. In this review, we critically examine recent advancements and findings related to the use of ncRNAs as biomarkers of HF and discuss their implication in fibrosis development.
Date Issued
2025-04-01
Date Acceptance
2025-04-02
Citation
Cells, 2025, 14 (7)
ISSN
2073-4409
Publisher
MDPI AG
Journal / Book Title
Cells
Volume
14
Issue
7
Copyright Statement
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40214506
PII: cells14070553
Subjects
biomarkers
BLOOD MONONUCLEAR-CELLS
cardiac fibrosis
CARDIAC-HYPERTROPHY
Cell Biology
circular RNAs
EPICARDIAL ADIPOSE-TISSUE
heart failure
HFpEF
HFrEF
Life Sciences & Biomedicine
LNCRNA H19
LONG
long non-coding RNAs
MICRORNA SIGNATURES
microRNAs
ncRNAs
NEGATIVE REGULATOR
PREDICTS SURVIVAL
PRESERVED EJECTION FRACTION
PROMOTES MYOCARDIAL FIBROSIS
Science & Technology
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
553
Date Publish Online
2025-04-07