Zinc and diabetes
File(s)
Accepted version
Author(s)
Chabosseau, P
Rutter, GA
Type
Journal Article
Abstract
Zn(2+) ions are essential for the normal processing and storage of insulin and altered pancreatic insulin content is associated with all forms of diabetes mellitus. Work of the past decade has identified variants in the human SLC30A8 gene, encoding the zinc transporter ZnT8 which is expressed highly selectively on the secretory granule of pancreatic islet β and α cells, as affecting the risk of Type 2 Diabetes. Here, we review the regulation and roles of Zn(2+) ions in islet cells, the mechanisms through which SLC30A8 variants might affect glucose homeostasis and diabetes risk, and the novel technologies including recombinant targeted zinc probes and knockout mice which have been developed to explore these questions.
Date Issued
2016-06-01
Date Acceptance
2016-05-31
Citation
Archives of Biochemistry and Biophysics, 2016, 611, pp.79-85
ISSN
1096-0384
Publisher
Elsevier
Start Page
79
End Page
85
Journal / Book Title
Archives of Biochemistry and Biophysics
Volume
611
Copyright Statement
© 2016 Published by Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
PII: S0003-9861(16)30186-2
Subjects
Beta cell
Diabetes
Insulin
Mouse
Zinc
Zinc probe
Publication Status
Published