Multifarious immunotherapeutic approaches to cure HIV-1 infection
File(s)
Author(s)
Imami, N
Herasimtschuk, AA
Type
Journal Article
Abstract
Immunotherapy in the context of treated HIV-1 infection aims to improve immune responses to achieve better control of the virus. To date, multifaceted immunotherapeutic approaches have been shown to reduce immune activation and increase CD4 T-lymphocyte counts, further to the effects of antiretroviral therapy alone, in addition to improving HIV-1-specific T-cell responses. While sterilizing cure of HIV-1 would involve elimination of all replication-competent virus, a functional cure in which the host has long-lasting control of viral replication may be more feasible. In this commentary, we discuss novel strategies aimed at targeting the latent viral reservoir with cure of HIV-1 infection being the ultimate goal, an achievement that would have considerable impact on worldwide HIV-1 infection.
Date Issued
2015-06-05
Date Acceptance
2015-02-15
Citation
Human Vaccines & Immunotherapeutics, 2015, 11 (9), pp.2287-2293
ISSN
2164-5515
Publisher
Taylor and Francis
Start Page
2287
End Page
2293
Journal / Book Title
Human Vaccines & Immunotherapeutics
Volume
11
Issue
9
Copyright Statement
© Nesrina Imami and Anna A Herasimtschuk 2015. This is an Open Access article distributed under the
terms of the Creative Commons Attribution-NonCommercial
License (http://creativecommons.org/
licenses/by-nc/3.0/), which permits unrestricted
non-commercial use, distribution, and reproduction
in any medium, provided the original work is properly
cited. The moral rights of the named author(s)
have been asserted.
terms of the Creative Commons Attribution-NonCommercial
License (http://creativecommons.org/
licenses/by-nc/3.0/), which permits unrestricted
non-commercial use, distribution, and reproduction
in any medium, provided the original work is properly
cited. The moral rights of the named author(s)
have been asserted.
License URL
Sponsor
Medical Research Council (MRC)
Westminster Medical School Research Trust
St Stephen's Aids Trust
St Stephen's Aids Trust
Westminster Medical School Research Trust
Grant Number
G0501957
JRC 10 / 11 R F 002
N/A
n/a
JRC FS 002 03/15-16
Subjects
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Immunology
antiretroviral therapy
functional cure
HIV-1
immunotherapy
retroviral persistence
T-cell responses
therapeutic vaccines
ACTIVE ANTIRETROVIRAL THERAPY
T-CELL RESPONSES
DOSE GROWTH-HORMONE
INTERLEUKIN-2 THERAPY
IN-VIVO
HIV-1-INFECTED INDIVIDUALS
IMMUNE RESTORATION
LATENT RESERVOIR
DNA VACCINE
CD4(+)
Humans
HIV Infections
Anti-Retroviral Agents
Immunotherapy
Combined Modality Therapy
Virus Latency
Adult
Aged
Aged, 80 and over
Middle Aged
Young Adult
Publication Status
Published