Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Advances in technology have allowed for the sensitive, specific, and simultaneous quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites, facilitating comprehensive characterization of the serum and urine steroid metabolomes. The quantification of steroid panels is therefore gaining favor over quantification of single marker metabolites in the clinical and research laboratories. However, although the biochemical pathways for the biosynthesis and metabolism of steroid hormones are now well defined, a gulf still exists between this knowledge and its application to the measured steroid profiles. In this review, we present an overview of steroid hormone biosynthesis and metabolism by the liver and peripheral tissues, specifically highlighting the pathways linking and differentiating the serum and urine steroid metabolomes. A brief overview of the methodology used in steroid profiling is also provided.
Date Issued
2019-11-01
Date Acceptance
2019-07-25
Citation
Journal of Steroid Biochemistry and Molecular Biology, 2019, 194
ISSN
0960-0760
Publisher
Elsevier
Journal / Book Title
Journal of Steroid Biochemistry and Molecular Biology
Volume
194
Copyright Statement
© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (https://creativecommons.org/licenses/BY/4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31362062
PII: S0960-0760(19)30279-1
Subjects
11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1
ADRENAL IN-VIVO
Biochemistry & Molecular Biology
CATECHOL-O-METHYLTRANSFERASE
Endocrinology & Metabolism
FATTY-ACID-ESTERS
GLUCOCORTICOID-REMEDIABLE ALDOSTERONISM
HUMAN LIVER
KETO REDUCTASE SUPERFAMILY
Life Sciences & Biomedicine
MASS-SPECTROMETRIC ANALYSIS
PLACENTAL 3-BETA-HYDROXY-5-ENE-STEROID DEHYDROGENASE
Science & Technology
Serum metabolome
Steroid biosynthesis
Steroid metabolism
Steroid metabolome
UDP-GLUCURONOSYLTRANSFERASES
Urine metabolome
Publication Status
Published
Coverage Spatial
England
Article Number
105439
Date Publish Online
2019-07-27