Arterial stiffness drives gender differences in vasculoventricular coupling in hypertensive patients but not patients with heart failure with preserved ejection fraction
Author(s)
Type
Conference Paper
Abstract
Background: Previous studies have demonstrated altered vasculoventricular coupling (VVC) between hypertensive men vs. women. VVC, defined as the ratio between arterial elastance (Ea) and ventricular elastance (Ees), is an important determinant of cardiovascular performance. VVC is also perturbed in patients with heart failure with preserved ejection fraction (HFpEF).
Purpose: To investigate gender-based differences in vasculoventricular coupling and compare between hypertensive patients and patients with HFpEF.
Methods: We retrospectively analysed echocardiographic data from a large prospective community study of older patients (>60 years) investigating the incidence of HFpEF in the general population, and age-matched hypertensive controls, to calculate VVC.
Results: There were 743 hypertensive patients (360/48% female) and 154 patients with HFpEF (110/71% female). VVC was maintained at ∼1 in all patient groups at rest, however Ea and Ees were both significantly higher in hypertensive women compared to men (p<0.001 for both), but not in HFpEF women compared to HFpEF men. On multivariate analysis in the hypertensive group, gender no longer remained as a significant predictor of Ea, which was predicted by systolic BP, heart rate, arterial compliance, and vascular resistance.
Purpose: To investigate gender-based differences in vasculoventricular coupling and compare between hypertensive patients and patients with HFpEF.
Methods: We retrospectively analysed echocardiographic data from a large prospective community study of older patients (>60 years) investigating the incidence of HFpEF in the general population, and age-matched hypertensive controls, to calculate VVC.
Results: There were 743 hypertensive patients (360/48% female) and 154 patients with HFpEF (110/71% female). VVC was maintained at ∼1 in all patient groups at rest, however Ea and Ees were both significantly higher in hypertensive women compared to men (p<0.001 for both), but not in HFpEF women compared to HFpEF men. On multivariate analysis in the hypertensive group, gender no longer remained as a significant predictor of Ea, which was predicted by systolic BP, heart rate, arterial compliance, and vascular resistance.
Date Issued
2018-08-01
Date Acceptance
2018-08-01
Citation
European Heart Journal, 2018, 39, pp.286-286
ISSN
0195-668X
Publisher
Oxford University Press (OUP)
Start Page
286
End Page
286
Journal / Book Title
European Heart Journal
Volume
39
Copyright Statement
© The European Society of Cardiology 2018. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices)
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000459824000846&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Source
European-Society-of-Cardiology Congress
Subjects
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Publication Status
Published
Start Date
2018-08-25
Finish Date
2018-08-29
Coverage Spatial
Munich, GERMANY
Date Publish Online
2019-08-28