A unique case of extraovarian sex-cord stromal fibrosarcoma, with subsequent relapse of differentiated sex-cord tumor
File(s)Fibrosarcoma.docx (53.39 KB)
Accepted version
Author(s)
Type
Journal Article
Abstract
Primary fibrosarcoma arising from ovarian sex-cord stroma is a very rare neoplasm, with only a few reports in the literature. These tumors have been reported to express inhibin which allows their distinction from fibrosarcomas of soft tissue. Here, we report a case of a fibrosarcoma arising in the broad ligament. Despite being totally separate from the ovary, the tumor was diagnosed as sex-cord stromal type on the basis of inhibin expression. Furthermore, this patient suffered a recurrence of her tumor in the pelvis, which showed both the fibrosarcomatous, as well as other sex-cord elements, confirming the sex-cord stromal differentiation of the sarcoma. To our knowledge, this is the first case of a sex-cord stromal fibrosarcoma arising from an extraovarian site. Furthermore, this is also the first case of a recurrent fibrosarcoma, which showed redifferentiation of the tumor into other sex-cord components.
Date Issued
2015-07-01
Date Acceptance
2015-07-01
Citation
International Journal of Gynecological Pathology, 2015, 34 (4), pp.363-368
ISSN
0277-1691
Publisher
Lippincott, Williams & Wilkins
Start Page
363
End Page
368
Journal / Book Title
International Journal of Gynecological Pathology
Volume
34
Issue
4
Copyright Statement
©2015 International Society of Gynecological Pathologists.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000356588400008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Obstetrics & Gynecology
Pathology
Sex-cord tumor
Fibrosarcoma
Ovary
Recurrence
PROBABLE WOLFFIAN ORIGIN
FEMALE ADNEXAL TUMOR
FIBROTHECOMATOUS TUMOR
CELLULAR FIBROMAS
OVARY
Publication Status
Published