Peracetic acid: An atom-economical reagent for Pd-catalyzed acetoxylation of C-H bonds
File(s)
Accepted version
Author(s)
Mulligan, Christopher
Bagale, Sharanappa
Newton, Oliver
Parker, Jeremy
Hii, King Kuok
Type
Journal Article
Abstract
Peracetic acid can be used universally as a source of acetate and an oxidant for the selective acetoxylation of C–H bonds in compounds containing ortho-directing groups, catalyzed by Pd(OAc)2. Compared to previous procedures, where persulfates and PhI(OAc)2 were used, the new protocol provides significant improvements in atom efficiency, product yield, substrate scope, cost, scalability, and environmental impact.
Date Issued
2019-01-07
Date Acceptance
2018-12-11
Citation
ACS Sustainable Chemistry and Engineering, 2019, 7 (1), pp.1611-1615
ISSN
2168-0485
Publisher
American Chemical Society
Start Page
1611
End Page
1615
Journal / Book Title
ACS Sustainable Chemistry and Engineering
Volume
7
Issue
1
Copyright Statement
© 2018 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Sustainable Chemistry & Engineering, after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acssuschemeng.8b05370
Sponsor
Engineering and Physical Sciences Research Council
Grant Number
EP/L50547X/1
Subjects
Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Green & Sustainable Science & Technology
Engineering, Chemical
Chemistry
Science & Technology - Other Topics
Engineering
Acetoxylation of C-H bonds
Palladium
Peracetic acid
Atom economy
ANILIDES
ACTIVATION
ARYLATION
FUNCTIONALIZATIONS
ACETANILIDES
OXIDATION
MILD
Publication Status
Published
Date Publish Online
2018-12-11