Quantitatively characterizing the microstructural features of breast ductal carcinoma tissues in different progression stages by Mueller matrix microscope
Author(s)
Type
Journal Article
Abstract
Polarization imaging has been recognized as a potentially powerful technique for probing the microstructural information and optical properties of complex biological specimens. Recently, we have reported a Mueller matrix microscope by adding the polarization state generator and analyzer (PSG and PSA) to a commercial transmission-light microscope, and applied it to differentiate human liver and cervical cancerous tissues with fibrosis. In this paper, we apply the Mueller matrix microscope for quantitative detection of human breast ductal carcinoma samples at different stages. The Mueller matrix polar decomposition and transformation parameters of the breast ductal tissues in different regions and at different stages are calculated and analyzed. For more quantitative comparisons, several widely-used image texture feature parameters are also calculated to characterize the difference in the polarimetric images. The experimental results indicate that the Mueller matrix microscope and the polarization parameters can facilitate the quantitative detection of breast ductal carcinoma tissues at different stages.
Date Issued
2017-07-13
Date Acceptance
2017-07-10
Citation
BIOMEDICAL OPTICS EXPRESS, 2017, 8 (8), pp.3643-3655
ISSN
2156-7085
Publisher
Optical Society of America
Start Page
3643
End Page
3655
Journal / Book Title
BIOMEDICAL OPTICS EXPRESS
Volume
8
Issue
8
Copyright Statement
© 2017 Optical Society of America. This article is Open Access under a a CC BY license (https://creativecommons.org/licenses/by/4.0/)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000407011200011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemical Research Methods
Optics
Radiology, Nuclear Medicine & Medical Imaging
Biochemistry & Molecular Biology
POLARIZED-LIGHT
CANCEROUS TISSUES
SCATTERING MEDIA
DECOMPOSITION
SPECTROSCOPY
PARAMETERS
DIAGNOSIS
BURDEN
(110.5405) Polarimetric imaging
(170.3880) Medical and biological imaging
(290.5855) Scattering, polarization
Publication Status
Published