Global disease burden estimates of respiratory syncytial virus associated with acute respiratory infections in older adults in 015: a systemic review and meta-analysis
File(s)
Accepted version
Author(s)
Openshaw, Peter
Type
Journal Article
Abstract
Respiratory syncytial virus associated acute respiratory infection (RSV-ARI)constitutes a substantial disease burden in older adults≥65 years. We aimed to identify all studies worldwide investigating the disease burden ofRSV-ARIin this population. We estimated thecommunityincidence, hospitalisationrate and in-hospital case fatality ratio (hCFR) of RSV-ARI in older adults stratified by industrialized anddeveloping regions, with data from a systematic review ofstudies published between January 1996 and April 2018, and from 8 unpublished population-based studies. We applied these rate estimates to population estimates for 2015, to calculate the global and regional burdenin older adults with RSV-ARIin community and in hospital duringthat year. We estimated thenumber ofin-hospital RSV-ARIdeaths by combining hCFR with hospital admission estimates from hospital-based studies. In 2015, there were about 1.5million(95% CI 0.3-6.9) episodes of RSV-ARIin older adults in41industrialised countries (data missing in developing countries), and of these 214,000 (~14.5%; 95% CI 100,000-459,000) were admitted to hospitals. The global number of hospital admissionsforRSV-ARI in older adults was estimated at 336,000 (UR 186,000-614,000).We further estimated about 14,000 (UR 5,000-50,000) in-hospital deaths related to RSV-ARIglobally.The hospital admission rate and hCFR were higher for those ≥65 years than those aged 50-64 years. The disease burden of RSV-ARIamong older adults is substantialwith limited data from developing countries; appropriate prevention and management strategiesare needed to reduce this burden.
Date Issued
2020-11-01
Date Acceptance
2019-01-25
Citation
Journal of Infectious Diseases, 2020, 222 (Suppl. 7), pp.S577-S583
ISSN
0022-1899
Publisher
Oxford University Press (OUP)
Start Page
S577
End Page
S583
Journal / Book Title
Journal of Infectious Diseases
Volume
222
Issue
Suppl. 7
Copyright Statement
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. This is a pre-copy-editing, author-produced version of an article accepted for publication in Journal of Infectious Diseases following peer review. The definitive publisher-authenticated version is available online at: https://academic.oup.com/jid/article/222/Supplement_7/S577/5382266
Subjects
Respiratory syncytial virus
acute respiratory infection
disease burden
older adults
RESCEU Investigators
06 Biological Sciences
11 Medical and Health Sciences
Microbiology
Publication Status
Published
Date Publish Online
2019-03-18