Geographic distribution and environmental risk factors of lymphoma in dogs under primary-care in the UK.
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
OBJECTIVES: To integrate external data sources with VetCompass postcode data to explore the spatial distribution and examine potential associations with environmental risk factors in dogs diagnosed with lymphoma at primary care veterinary practices. MATERIALS AND METHODS: Cases of lymphoma were identified from electronic patient records of 455,553 dogs under primary veterinary care during 2013 in the UK. Cases were defined as either laboratory-confirmed or non-laboratory-confirmed. Disease maps at the postcode-district level were used to define the geographic distribution of lymphoma incidence and spatial clustering was explored. Environmental risk factors from external data sources were transferred to a compatible format and logistic regression modelling was used to examine associations between environmental herbicide, fungicide and radon concentrations with lymphoma. RESULTS: From the denominator population of 455,553 dogs, 279 lymphoma cases (187 with laboratory confirmation and 93 without) were identified. Heterogeneous geographic variation was observed with weak evidence of clustering around London and the south-west of England. Herbicide and fungicide exposures were weakly associated with a diagnosis of lymphoma in the univariable analysis. After accounting for the age at diagnosis and breed in the multivariable analysis, herbicide exposure was associated with a diagnosis of lymphoma. CLINICAL SIGNIFICANCE: The heterogeneous distribution of lymphoma in UK dogs provides further evidence for geographic variation of lymphoma, perhaps in part associated with underlying environmental risk factors. The results suggest an association between environmental herbicide and canine lymphoma.
Date Issued
2019-12
Date Acceptance
2019-09-20
Citation
Journal of Small Animal Practice, 2019, 60 (12), pp.746-754
ISSN
0022-4510
Publisher
Wiley
Start Page
746
End Page
754
Journal / Book Title
Journal of Small Animal Practice
Volume
60
Issue
12
Copyright Statement
© 2019 British Small Animal Veterinary Association. This is the accepted version of the following article: Schofield, I. , Stevens, K. B., Pittaway, C. , O'Neill, D. G., Fecht, D. , Dobson, J. M. and Brodbelt, D. C. (2019), Geographic distribution and environmental risk factors of lymphoma in dogs under primary‐care in the UK. J Small Anim Pract, which has been published in final form at https://doi.org/10.1111/jsap.13075
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31709551
Subjects
Science & Technology
Life Sciences & Biomedicine
Veterinary Sciences
CANINE MALIGNANT-LYMPHOMA
NON-HODGKINS-LYMPHOMA
AGRICULTURAL USE
INCIDENCE RATES
ASSOCIATION
POPULATION
LEUKEMIA
EXPOSURE
RADON
Veterinary Sciences
0707 Veterinary Sciences
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2019-11-10