Parkinson's disease deficits in time perception to auditory as well as visual stimuli - A large online study
Author(s)
Su, Zi H
Patel, Salil
Bredemeyer, Oliver
FitzGerald, James J
Antoniades, Chrystalina A
Type
Journal Article
Abstract
Cognitive deficits are common in Parkinson's disease (PD) and range from mild cognitive impairment to dementia, often dramatically reducing quality of life. Physiological models have shown that attention and memory are predicated on the brain's ability to process time. Perception has been shown to be increased or decreased by activation or deactivation of dopaminergic neurons respectively. Here we investigate differences in time perception between patients with PD and healthy controls. We have measured differences in sub-second- and second-time intervals. Sensitivity and error in perception as well as the response times are calculated. Additionally, we investigated intra-individual response variability and the effect of participant devices on both reaction time and sensitivity. Patients with PD have impaired sensitivity in discriminating between durations of both visual and auditory stimuli compared to healthy controls. Though initially designed as an in-person study, because of the pandemic the experiment was adapted into an online study. This adaptation provided a unique opportunity to enroll a larger number of international participants and use this study to evaluate the feasibility of future virtual studies focused on cognitive impairment. To our knowledge this is the only time perception study, focusing on PD, which measures the differences in perception using both auditory and visual stimuli. The cohort involved is the largest to date, comprising over 800 participants.
Date Issued
2022-10-20
Date Acceptance
2022-09-26
Citation
Frontiers in Neuroscience, 2022, 16
ISSN
1662-453X
Publisher
Frontiers Media S.A.
Journal / Book Title
Frontiers in Neuroscience
Volume
16
Copyright Statement
© 2022 Su, Patel, Bredemeyer, FitzGerald and Antoniades. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/36340785
Subjects
auditory stimuli
online testing and experimentation
Parkinson’s disease
time perception
visual stimuli
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
ARTN 995438