Adverse Outcome Pathways can drive non-animal approaches for safety assessment.
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Adverse Outcome Pathways (AOPs) provide an opportunity to develop new and more accurate safety assessment processes for drugs and other chemicals, and may ultimately play an important role in regulatory decision making. Not only can the development and application of AOPs pave the way for the development of improved evidence-based approaches for hazard and risk assessment, there is also the promise of a significant impact on animal welfare, with a reduced reliance on animal-based methods. The establishment of a useable and coherent knowledge framework under which AOPs will be developed and applied has been a first critical step towards realizing this opportunity. This article explores how the development of AOPs under this framework, and their application in practice, could benefit the science and practice of safety assessment, while in parallel stimulating a move away from traditional methods towards an increased acceptance of non-animal approaches. We discuss here the key areas where current, and future initiatives should be focused to enable the translation of AOPs into routine chemical safety assessment, and lasting 3Rs benefits. © 2015 The Authors. Journal of Applied Toxicology published by John Wiley & Sons Ltd.
Date Issued
2015-05-05
Date Acceptance
2015-03-19
Citation
Journal of Applied Toxicology, 2015, 35 (9), pp.971-975
ISSN
1099-1263
Publisher
Wiley
Start Page
971
End Page
975
Journal / Book Title
Journal of Applied Toxicology
Volume
35
Issue
9
Copyright Statement
© 2015 The Authors. This is an open access article under the terms of the Creative Commons Attribution
License, which permits use, distribution and reproduction in any medium, provided
the original work is properly cited.
License, which permits use, distribution and reproduction in any medium, provided
the original work is properly cited.
License URL
Subjects
3Rs
AOP
chemical
mechanism of action
mode of action
pathway
risk
safety assessment
toxicity
Publication Status
Published