In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia
File(s)d0cb00140f.pdf (4.27 MB)
Published version
Author(s)
Type
Journal Article
Abstract
To image activated microglia, a small-molecule FPR2/ALX-targeted fluorescent probe was locally delivered into the brain using focused ultrasound and microbubbles. The probe did not co-localise with neurons or astrocytes but accumulated in activated microglia, making this a potential imaging tool for future drug discovery programs focused on neurological disorders.
Date Issued
2020-09-23
Date Acceptance
2020-09-11
Citation
RSC Chemical Biology, 2020, 1 (5), pp.385-389
ISSN
2633-0679
Publisher
Royal Society of Chemistry
Start Page
385
End Page
389
Journal / Book Title
RSC Chemical Biology
Volume
1
Issue
5
Copyright Statement
© The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence http://creativecommons.org/licenses/by-nc/3.0/.
License URL
Identifier
https://pubs.rsc.org/en/content/articlelanding/2020/CB/D0CB00140F#!divAbstract
Publication Status
Published
Date Publish Online
2020-09-23