Self-limiting population genetic control with sex-linked genome editors
File(s)
Author(s)
Burt, Austin
Deredec, Anne
Type
Journal Article
Abstract
In male heterogametic species the Y chromosome is transmitted solely from fathers to sons, and is selected for based only on its impacts on male fitness. This fact can be exploited to develop efficient pest control strategies that use Y-linked editors to disrupt the fitness of female descendants. With simple population genetic and dynamic models we show that Y-linked editors can be substantially more efficient than other self-limiting strategies and, while not as efficient as gene drive approaches, are expected to have less impact on non-target populations with which there is some gene flow. Efficiency can be further augmented by simultaneously releasing an autosomal X-shredder construct, in either the same or different males. Y-linked editors may be an attractive option to consider when efficient control of a species is desired in some locales but not others.
Date Issued
2018-07-25
Date Acceptance
2018-06-28
Citation
Proceedings of the Royal Society B: Biological Sciences, 2018, 285 (1883), pp.1-9
ISSN
0962-8452
Publisher
The Royal Society
Start Page
1
End Page
9
Journal / Book Title
Proceedings of the Royal Society B: Biological Sciences
Volume
285
Issue
1883
Copyright Statement
© 2018 The Authors.
Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000439907900011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Biology
Ecology
Evolutionary Biology
Life Sciences & Biomedicine - Other Topics
Environmental Sciences & Ecology
pest control
sterile insect technique
gene drive
gene editing
CRISPR
Y-linked editors
ANOPHELES-GAMBIAE
DRIVE SYSTEM
PEST-CONTROL
RATIO
REQUIREMENTS
SUPPRESSION
ELIMINATION
DISEASES
RELEASE
Publication Status
Published
Article Number
ARTN 20180776
Date Publish Online
2018-07-25