Utility and interpretation of multiple breath washout in children with cystic fibrosis
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Transformative changes in the health of children with cystic fibrosis (CF) mean that more sensitive outcome measures are needed to monitor paediatric CF lung disease. Multiple breath washout (MBW) and its primary readout lung clearance index are gaining increasing traction as an endpoint for clinical trials in the CF space and show promise as a clinical investigation. In this article, we use four clinically based questions to explore what MBW can and cannot (yet) do and highlight some of its strengths and weaknesses as an investigation. We end by discussing how we can increase the utility of MBW as an investigation in children with CF.
Date Issued
2025-10-01
Date Acceptance
2024-12-31
Citation
Archives of Disease in Childhood: Education and Practice Edition, 2025, 110 (5), pp.214-217
ISSN
1743-0585
Publisher
BMJ Publishing Group
Start Page
214
End Page
217
Journal / Book Title
Archives of Disease in Childhood: Education and Practice Edition
Volume
110
Issue
5
Copyright Statement
Copyright © Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy)
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39805677
PII: archdischild-2024-328203
Subjects
BRONCHIECTASIS
CLINICAL-TRIALS
Cystic Fibrosis
DISEASE
INFANTS
Life Sciences & Biomedicine
LUNG CLEARANCE INDEX
Pediatrics
Physiology
PULMONARY EXACERBATIONS
Respiratory Medicine
Science & Technology
SPIROMETRY
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2025-01-13