Fabrication and Characterization of Ceftizoxime Loaded Pectin Nanocarriers
File(s)
Published version
Author(s)
Kumar, Pawan
Kumar, Vinod
Kumar, Ravinder
Pruncu, Catalin
Type
Journal Article
Abstract
Ceftizoxime (C13H12N5NaO5S2) is a parenteral, third-generationcephalosporin antibiotic used to treat bacterial infections including ear, nose, and throat infections. In this work, pectin has been used as a nanocarrier for ceftizoxime due to its high biocompatibility and non-toxicity with tunable surface properties. Ceftizoxime-loaded pectin nanocarriers (CPN) were successfully synthesized by the solvent displacement method. Optimization of nanoformulation was done by response surface methodology using Design-Expert software. The optimized formulation examined various in-vitro characterizations such as particle size, morphology, and FTIR studies. TEM results revealed irregular shape nanoparticles within the range of 29–110 nm. The in-vitro drug release using the dialysis method was performed after 24 h where nanoformulation showed sustained drug release. Drug-loaded nanoparticles revealed good antimicrobial activity against Bacillus cereus, Bacillus polymyxa, Enterobacter aerogenes, and Pseudomonas aeruginosa.
Date Issued
2020-07-24
Date Acceptance
2020-07-21
Citation
Nanomaterials, 2020, 10 (8)
ISSN
2079-4991
Publisher
MDPI AG
Journal / Book Title
Nanomaterials
Volume
10
Issue
8
Copyright Statement
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
License URL
Subjects
Ceftizoxime
antibacterial activity
nanocarriers
pectin
solvent displacement
0912 Materials Engineering
1007 Nanotechnology
Publication Status
Published
Article Number
ARTN 1542