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  4. Parallel transmit pulse design for saturation homogeneity (PUSH) for magnetization transfer imaging at 7T
 
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Parallel transmit pulse design for saturation homogeneity (PUSH) for magnetization transfer imaging at 7T
File(s)
Parallel transmit pulse design for saturation homogeneity (PUSH) for magnetization transfer imaging at 7T.pdf (6.54 MB)
Published version
Author(s)
Leitao, David
Tomi-Tricot, Raphael
Bridgen, Pip
Wilkinson, Tom
Liebig, Patrick
more
Type
Journal Article
Abstract
Purpose: This work proposes a novel RF pulse design for parallel transmit(pTx) systems to obtain uniform saturation of semisolid magnetization formagnetization transfer (MT) contrast in the presence of transmit field (B+1)inhomogeneities. The semisolid magnetization is usually modeled as beingpurely longitudinal, with the applied B+1 field saturating but not rotating itsmagnetization; thus, standard pTx pulse design methods do not apply.Theory and Methods: Pulse design for saturation homogeneity (PUSH) opti-mizes pTx RF pulses by considering uniformity of root-mean squared B+1 , Brms1 ,which relates to the rate of semisolid saturation. Here we considered designsconsisting of a small number of spatially non-selective sub-pulses optimized overeither a single 2D plane or 3D. Simulations and in vivo experiments on a 7T Terrasystem with an 8-TX Nova head coil in five subjects were carried out to study thehomogenization of Brms1 and of the MT contrast by acquiring MT ratio maps.Results: Simulations and in vivo experiments showed up to six and two timesmore uniform Brms1 compared to circular polarized (CP) mode for 2D and 3Doptimizations, respectively. This translated into 4 and 1.25 times more uniformMT contrast, consistently for all subjects, where two sub-pulses were enough forthe implementation and coil used.Conclusion: The proposed PUSH method obtains more uniform and higher MTcontrast than CP mode within the same specific absorption rate (SAR) budget.
Date Issued
2022-07-01
Date Acceptance
2022-01-25
Citation
Magnetic Resonance in Medicine, 2022, 88 (1), pp.180-194
URI
https://hdl.handle.net/10044/1/119010
DOI
https://www.dx.doi.org/10.1002/mrm.29199
ISSN
0740-3194
Publisher
Wiley
Start Page
180
End Page
194
Journal / Book Title
Magnetic Resonance in Medicine
Volume
88
Issue
1
Copyright Statement
© 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
http://creativecommons.org/licenses/by/4.0/
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000766526500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
B-1(+) INHOMOGENEITY MITIGATION
EXCHANGE
EXCITATION
FLIP-ANGLE
HUMAN BRAIN
Life Sciences & Biomedicine
magnetization transfer
math> inhomogeneity
media
mn><mml
mn>1</mml
MODEL
msubsup><mml
OPTIMIZATION
parallel transmit
RADIOFREQUENCY PULSE
Radiology, Nuclear Medicine & Medical Imaging
RF pulse design
RF PULSES
Science & Technology
SYSTEMS
ultrahigh-field
x-wiley
Publication Status
Published
Date Publish Online
2022-03-10
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