Nanoengineering of poly(ethylene glycol) particles for stealth and targeting
File(s)
Accepted version
Author(s)
Cui, Jiwei
Bjornmalm, AMH
Ju, Yi
Caruso, Frank
Type
Journal Article
Abstract
The assembly of particles composed solely or mainly of poly(ethylene glycol) (PEG) is an emerging area that is gaining increasing interest within bio−nano science. PEG, widely considered to be the “gold standard” among polymers for drug delivery, is providing a platform for exploring fundamental questions and phenomena at the interface between particle engineering and biomedicine. These include the targeting and stealth behaviors of synthetic nanomaterials in biological environments. In this feature article, we discuss recent work in the nanoengineering of PEG particles and explore how they are enabling improved targeting and stealth performance. Specific examples include PEG particles prepared through surface-initiated polymerization, mesoporous silica replication via postinfiltration, and particle assembly through metal–phenolic coordination. This particle class exhibits unique in vivo behavior (e.g., biodistribution and immune cell interactions) and has recently been explored for drug delivery applications.
Date Issued
2018-09-18
Date Acceptance
2018-08-09
Citation
Langmuir, 2018, 34 (37), pp.10817-10827
ISSN
0743-7463
Publisher
American Chemical Society
Start Page
10817
End Page
10827
Journal / Book Title
Langmuir
Volume
34
Issue
37
Copyright Statement
© 2018 American Chemical Society
Sponsor
European Commission
Grant Number
745676
Subjects
Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Materials Science, Multidisciplinary
Chemistry
Materials Science
STOP-FLOW LITHOGRAPHY
RED-BLOOD-CELLS
METAL-PHENOLIC NETWORKS
BIO-NANO SCIENCE
DRUG-DELIVERY
POLYMERIC NANOPARTICLES
PROTEIN CORONA
IN-VIVO
CONTROLLED PERMEABILITY
ENHANCED PERMEABILITY
MD Multidisciplinary
Chemical Physics
Publication Status
Published
Date Publish Online
2018-08-22