A new dawn for androgens: novel lessons from 11-oxygenated C19 steroids
Author(s)
Pretorius, Elzette
Ark, Wiebke
Storbeck, Karl-Heinz
Type
Journal Article
Abstract
The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has demonstrated that 11OHA4 is the precursor to the potent androgenic 11-oxygenated steroids, 11-ketotestosterone and 11-ketodihydrotestosterone, that bind and activate the human androgen receptor similarly to testosterone and DHT. The significance of this discovery becomes apparent when considering androgen dependent diseases such as castration resistant prostate cancer and diseases associated with androgen excess, e.g. congenital adrenal hyperplasia and polycystic ovary syndrome. In this review we describe the production and metabolism of 11-oxygenated steroids. We subsequently discuss their androgenic activity and highlight the putative role of these androgens in disease states.
Date Issued
2017-02-05
Date Acceptance
2016-08-08
Citation
Molecular and Cellular Endocrinology, 2017, 441, pp.76-85
ISSN
0303-7207
Publisher
Elsevier
Start Page
76
End Page
85
Journal / Book Title
Molecular and Cellular Endocrinology
Volume
441
Copyright Statement
© 2016 Elsevier Ireland Ltd. All rights reserved.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/27519632
PII: S0303-7207(16)30308-2
Subjects
11-Ketodihydrotestosterone (11KDHT)
11-Ketotestosterone (11KT)
21-HYDROXYLASE DEFICIENCY
3-BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA(5)-DELTA(4) ISOMERASE
Adrenal androgens
BETA-HYDROXYANDROSTENEDIONE
Castration resistant prostate cancer (CRPC)
Cell Biology
Congenital adrenal hyperplasia (CAH)
CONGENITAL ADRENAL-HYPERPLASIA
CYTOCHROME B(5) AUGMENTS
DEHYDROEPIANDROSTERONE-SULFATE
Endocrinology & Metabolism
HIRSUTE WOMEN
Life Sciences & Biomedicine
ORAL DEHYDROEPIANDROSTERONE
Polycystic ovary syndrome (PCOS)
POLYCYSTIC-OVARY-SYNDROME
RESISTANT PROSTATE-CANCER
Science & Technology
Publication Status
Published
Coverage Spatial
MA, Boston
Date Publish Online
2016-08-09