A simplified computational workflow for evaluation of aortic hemodynamics after frozen elephant trunk intervention in type A aortic dissection
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Accepted version
Author(s)
Zhu, Yu
Xu, Xiao Yun
Rosendahl, Ulrich
Pepper, John
Mirsadraee, Saeed
Type
Journal Article
Abstract
This study aimed to predict the hemodynamic performance of frozen elephant trunk (FET) intervention in surgically repaired type A aortic dissection (TAAD) patients through computational simulations of post-operative scenarios. Patient-specific geometries of a single patient were reconstructed from pre- and post-FET intervention computed tomography angiography (CTA) images. The pre-FET geometry was used to create post-FET geometry through anatomical modifications and a simplified finite element simulation to inflate the stented true lumen (TL) segment. Computational fluid dynamics (CFD) simulations were then performed on the virtually created post-FET geometry, and the results were compared with those obtained with the actual post-FET geometry. Various intervention scenarios with different stent-graft (SG) lengths and TL volume expansion were also simulated and compared to study their impacts on hemodynamic performance. A good overall agreement was achieved between the virtual and real post-FET models, with the maximum difference in true and false lumen (FL) pressures along the dissected aorta being 4.2%. Simulation results for the actual intervention revealed high wall shear stress (WSS) and pressure around a distal tear that was found to have expanded on post-FET scan. Extending the SG length dramatically reduced the maximum WSS and pressure around the distal tear. This pilot study demonstrates the feasibility of using the simplified simulation workflow for personalized assessment of aortic hemodynamics following FET intervention in repaired TAAD. Further studies in a large patient cohort are warranted.
Date Issued
2023-06
Date Acceptance
2023-02-02
Citation
International Journal of Applied Mechanics, 2023, 15 (5)
ISSN
1758-8251
Publisher
World Scientific Publishing
Journal / Book Title
International Journal of Applied Mechanics
Volume
15
Issue
5
Copyright Statement
Copyright Electronic version of an article published as International Journal of Applied Mechanics https://doi.org/10.1142/S1758825123500333 © copyright World Scientific Publishing Company https://www.worldscientific.com/doi/10.1142/S1758825123500333
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000958332700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
ANEURYSM
ARCH
Computational fluid dynamics
DYNAMICS
ENDOVASCULAR REPAIR
ENLARGEMENT
ENTRY
FALSE LUMEN
FATE
finite element analysis
frozen elephant trunk
Mechanics
REPLACEMENT
Science & Technology
STENT
Technology
type A aortic dissection
virtual-FET simulation
Publication Status
Published
Article Number
23500033
Date Publish Online
2023-03-22