Metabolic biomarkers of squamous cell carcinoma of the aerodigestive tract: a systematic review and quality assessment
File(s)
Published version
Author(s)
Goh, Yan Mei
Antonowicz, Stefan
Boshier, Piers
Hanna, George
Type
Journal Article
Abstract
Introduction. Aerodigestive squamous cell carcinomas (ASCC) constitute a major source of global cancer deaths. Patients typically present with advanced, incurable disease, so new means of detecting early disease are a research priority. Metabolite quantitation is amenable to point-of-care analysis and can be performed in ASCC surrogates such as breath and saliva. The purpose of this systematic review is to summarise progress of ASCC metabolomic studies, with an emphasis on the critical appraisal of methodological quality and reporting. Method. A systematic online literature search was performed to identify studies reporting metabolic biomarkers of ASCC. This review was conducted in accordance with the recommendations of the Cochrane Library and MOOSE guidelines. Results. Thirty studies comprising 2117 patients were included in the review. All publications represented phase-I biomarker discovery studies, and none validated their findings in an independent cohort. There was heterogeneity in study design and methodological and reporting quality. Sensitivities and specificities were higher in oesophageal and head and neck squamous cell carcinomas compared to those in lung squamous cell carcinoma. The metabolic phenotypes of these cancers were similar, as was the kinetics of metabolite groups when comparing blood, tissue, and breath/saliva concentrations. Deregulation of amino acid metabolism was the most frequently reported theme. Conclusion. Metabolite analysis has shown promising diagnostic performance, especially for oesophageal and head and neck ASCC subtypes, which are phenotypically similar. However, shortcomings in study design have led to inconsistencies between studies. To support future studies and ultimately clinical adoption, these limitations are discussed.
Date Issued
2020-02-21
Date Acceptance
2020-01-21
Citation
Oxidative Medicine and Cellular Longevity, 2020, 2020, pp.1-13
ISSN
1942-0900
Publisher
Hindawi Publishing Corporation
Start Page
1
End Page
13
Journal / Book Title
Oxidative Medicine and Cellular Longevity
Volume
2020
Copyright Statement
© 2020 Yan Mei Goh et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor
Medical Research Council (MRC)
Identifier
https://www.hindawi.com/journals/omcl/2020/2930347/
Grant Number
MR/S022112/1
Subjects
11 Medical and Health Sciences
Publication Status
Published
Article Number
ARTN 2930347
Date Publish Online
2020-02-21