Circadian and diurnal regulation of cerebral blood flow
File(s)
Author(s)
Webb, Alastair JS
Klerman, Elizabeth B
Mandeville, Emiri T
Type
Journal Article
Abstract
Circadian and diurnal variation in cerebral blood flow directly contributes to the diurnal variation in the risk of stroke, either through factors that trigger stroke or due to impaired compensatory mechanisms. Cerebral blood flow results from the integration of systemic hemodynamics, including heart rate, cardiac output, and blood pressure, with cerebrovascular regulatory mechanisms, including cerebrovascular reactivity, autoregulation, and neurovascular coupling. We review the evidence for the circadian and diurnal variation in each of these mechanisms and their integration, from the detailed evidence for mechanisms underlying the nocturnal nadir and morning surge in blood pressure to identifying limited available evidence for circadian and diurnal variation in cerebrovascular compensatory mechanisms. We, thus, identify key systemic hemodynamic factors related to the diurnal variation in the risk of stroke but particularly identify the need for further research focused on cerebrovascular regulatory mechanisms.
Date Issued
2024-03-15
Date Acceptance
2024-02-07
Citation
Circulation Research, 2024, 134 (6), pp.695-710
ISSN
0009-7330
Publisher
American Heart Association
Start Page
695
End Page
710
Journal / Book Title
Circulation Research
Volume
134
Issue
6
Copyright Statement
© 2024 The Authors. Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/38484025
Subjects
ACUTE ISCHEMIC-STROKE
ARTERIAL STIFFNESS
BEAT-TO-BEAT
blood pressure
Cardiac & Cardiovascular Systems
cardiovascular diseases
Cardiovascular System & Cardiology
cerebrovascular circulation
CEREBROVASCULAR CO2 REACTIVITY
HEALTHY HUMANS
heart disease risk factors
HEART-RATE
Hematology
Life Sciences & Biomedicine
Peripheral Vascular Disease
risk factors
Science & Technology
SLEEP-APNEA SYNDROME
SMALL VESSEL DISEASE
SYMPATHETIC-NERVE ACTIVITY
WHITE-MATTER
Publication Status
Published
Coverage Spatial
United States
Article Number
0009-7330
Date Publish Online
2024-03-14