Identifying biochemical reaction networks from heterogeneous datasets
File(s)
Author(s)
Pan, W
Yuan, Y
Ljung, L
Gonçalves, JM
Stan, G-B
Type
Conference Paper
Abstract
In this paper, we propose a new method to identify biochemical reaction networks (i.e. both reactions and kinetic parameters) from heterogeneous datasets. Such datasets can contain (a) data from several replicates of an experiment performed on a biological system; (b) data measured from a biochemical network subjected to different experimental conditions, for example, changes/perturbations in biological inductions, temperature, gene knock-out, gene over-expression, etc. Simultaneous integration of various datasets to perform system identification has the potential to avoid non-identifiability issues typically arising when only single datasets are used.
Date Issued
2016-02-11
Date Acceptance
2015-12-01
Citation
Proceedings of the 2015 IEEE 54th Annual Conference on Decision and Control (CDC), 2016, pp.2525-2530
ISBN
978-1-4799-7886-1
Publisher
IEEE
Start Page
2525
End Page
2530
Journal / Book Title
Proceedings of the 2015 IEEE 54th Annual Conference on Decision and Control (CDC)
Copyright Statement
© 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Sponsor
Microsoft Research Limited
Engineering & Physical Science Research Council (EPSRC)
Grant Number
MRL Contract # 2011-042
EP/M002187/1
Source
2015 IEEE 54th Annual Conference on Decision and Control (CDC)
Publication Status
Published
Start Date
2015-12-15
Finish Date
2015-12-18
Coverage Spatial
Osaka, Japan