Cardiovascular risk in non-alcoholic fatty liver disease: mechanisms and therapeutic implications
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
New evidence suggests that non-alcoholic fatty liver disease (NAFLD) has a strong multifaceted relationship with diabetes and metabolic syndrome, and is associated with increased risk of cardiovascular events, regardless of traditional risk factors, such as hypertension, diabetes, dyslipidemia, and obesity. Given the pandemic-level rise of NAFLD-in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome-and its association with poor cardiovascular outcomes, the question of how to manage NAFLD properly, in order to reduce the burden of associated incident cardiovascular events, is both timely and highly relevant. This review aims to summarize the current knowledge of the association between NAFLD and cardiovascular disease, and also to discuss possible clinical strategies for cardiovascular risk assessment, as well as the spectrum of available therapeutic strategies for the prevention and treatment of NAFLD and its downstream events.
Date Issued
2019-08-26
Date Acceptance
2019-08-21
Citation
International Journal of Environmental Research and Public Health, 2019, 16 (17)
ISSN
1660-4601
Publisher
MDPI AG
Journal / Book Title
International Journal of Environmental Research and Public Health
Volume
16
Issue
17
Copyright Statement
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31455011
PII: ijerph16173104
Subjects
cardiovascular disease
cardiovascular risk factors
metabolic syndrome
non-alcoholic fatty liver disease
Publication Status
Published online
Coverage Spatial
Switzerland