Knowledge dissemination in clinical trials: exploring influences of institutional support and type of innovation on selective reporting
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Published version
Author(s)
Salandra, R
Type
Journal Article
Abstract
This paper contributes to the ongoing debate on the reliability of published research. In particular, this study focuses on the selective reporting of research findings in clinical trials, defined as the publication of only part of the findings originally recorded during a research study, on the basis of the results. Selective reporting can lead to concerns ranging from publishing flawed scientific knowledge, to skewing medical evidence, to wasting time and resources invested in the conduct of research. Drawing upon a unique hand-collected dataset, this study investigates the contextual factors associated with selective reporting. Using ‘risk of bias’ ratings assessed based on expert judgment and presented in systematic reviews of clinical literature, this study explores whether selective reporting is associated with: (1) the source of institutional support; and, (2) the type of innovation evaluated. The results indicate that the odds of selective reporting are higher for industry-funded studies than for publicly-funded studies; however, this effect is restricted to studies where at least one author is industry-affiliated. In addition, the results suggest that selective reporting is more likely in projects exploring radical innovation, compared to those investigating incremental innovation.
Date Issued
2018-09-01
Date Acceptance
2018-04-03
Citation
Research Policy, 2018, 47 (7), pp.1215-1228
ISSN
0048-7333
Publisher
Elsevier
Start Page
1215
End Page
1228
Journal / Book Title
Research Policy
Volume
47
Issue
7
Copyright Statement
© 2018 The Author(s). This article is available under a Creative Commons Attribution Licence 4.0 (https://creativecommons.org/licenses/by/4.0/)
Subjects
Social Sciences
Management
Planning & Development
Business & Economics
Public Administration
Reliability of research
Reproducibility crisis
Science policy
Scientific misconduct
RANDOMIZED CONTROLLED-TRIALS
EVIDENCE-BASED MEDICINE
CONFLICT-OF-INTEREST
SCIENTIFIC PUBLICATIONS
INDUSTRY SPONSORSHIP
BIOMEDICAL-RESEARCH
FIRM PERFORMANCE
ADVERSE EVENTS
FILE DRAWER
SCIENCE
1503 Business And Management
Science Studies
Publication Status
Published
Date Publish Online
2018-04-17