Cell competition and the regulative nature of early mammalian development
File(s)
Author(s)
Nichols, Jennifer
Lima, Ana
Rodriguez, Tristan
Type
Journal Article
Abstract
The mammalian embryo exhibits a remarkable plasticity that allows it to correct for the presence of aberrant cells, adjust its growth so that its size is in accordance with its developmental stage, or integrate cells of another species to form fully functional organs. Here, we will discuss the contribution that cell competition, a quality control that eliminates viable cells that are less fit than their neighbours, makes to this plasticity. We will do this by reviewing the roles that cell competition plays in the early mammalian embryo and how they contribute to ensure normal development of the embryo.
Date Issued
2022-07-07
Date Acceptance
2022-06-08
Citation
Cell Stem Cell, 2022, 29 (7), pp.1018-1030
ISSN
1934-5909
Publisher
Elsevier
Start Page
1018
End Page
1030
Journal / Book Title
Cell Stem Cell
Volume
29
Issue
7
Copyright Statement
© 2022 Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
Grant Number
BB/S008284/1
MR/T028637/1
MR/W02425X/1
Subjects
Animals
Cell Competition
Embryo, Mammalian
Embryonic Development
Mammals
Animals
Mammals
Embryonic Development
Embryo, Mammalian
Cell Competition
Developmental Biology
06 Biological Sciences
11 Medical and Health Sciences
Publication Status
Published
Date Publish Online
2022-07-07