Mitochondrial polarization and redox homeostasis couple glycolysis-to- OXPHOS metabolic rewiring to lifespan extension in C. elegans
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Published version
Author(s)
Type
Journal Article
Abstract
Mitochondria are essential for maintaining cellular homeostasis throughout life. Here, we investigated the differential effects of glucose and galactose, as well as glycolytic inhibition, on C. elegans lifespan in relation to mitochondrial membrane potential and reactive oxygen species (ROS) levels. Our results show that long-term treatment with glucose reduces both lifespan and mitochondrial membrane potential, whereas galactose increases them. The increase in mitochondrial membrane potential and lifespan is inversely correlated with mitochondrial ROS levels, suggesting a role for mitohormesis in lifespan extension.
Date Issued
2025-11-19
Date Acceptance
2025-11-11
Citation
microPublication Biology, 2025, 2025
ISSN
2578-9430
Publisher
Caltech Library
Journal / Book Title
microPublication Biology
Volume
2025
Copyright Statement
© 2025 by the authors. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Publication Status
Published
Date Publish Online
2025-11-19