Meat consumption and cancer risk: a case-control study in Uruguay
File(s)
Author(s)
Type
Journal Article
Abstract
Introduction: There is strong evidence that high meat intake increases the risk of colorectal cancer. However,for other cancer sites there is currently less convincing evidence.
Methods: To further explore associations betweenmeat intake and cancer risk we conducted a multisite case-control study of 11 cancer sites in Uruguay between1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls. We used unconditional logistic regressionto estimate odds ratios and 95% confidence intervals of cancer associated with meat intake.
Results: In themultivariable model there was a significant increase in the odds of cancers of the oral cavity and pharynx(OR=3.65, 95% CI: 2.21-6.01), esophagus (OR=3.36, 95% CI: 1.97-5.72), larynx (OR=2.91, 95% CI: 1.80-4.68),stomach (OR=2.19, 95% CI: 1.31-3.65), colorectum (OR=3.83, 95% CI: 2.37-6.20), lung (OR=2.17, 95% CI:1.52-3.10), breast (OR=1.97, 95% CI: 1.04-3.75), prostate (OR=1.87, 95% CI: 1.08-3.21), bladder (OR=2.11,95% CI: 1.20-3.72) and kidney (OR=2.72, 95% CI: 1.22-6.07) with high intake of red meat and similar findingswere found for total meat. In addition, intake of beef and lamb were also associated with increased risk ofseveral cancer sites. High intake of processed meat was associated with increased risk of cancers of the esophagus(OR=1.63, 95% CI: 1.08-2.47), larynx (OR=1.84, 95% CI: 1.21-2.78), stomach (OR=1.62, 95% CI: 1.07-2.44),colorectum (OR=2.15, 95% CI: 1.49-3.11), lung (OR=1.70, 95% CI: 1.28-2.25) and breast (OR=1.53, 95% CI:1.01-2.30).
Conclusion: Our results confirm earlier findings of increased risk of digestive tract cancers, butsuggest that meat consumption also increases the risk of several other cancers.
Methods: To further explore associations betweenmeat intake and cancer risk we conducted a multisite case-control study of 11 cancer sites in Uruguay between1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls. We used unconditional logistic regressionto estimate odds ratios and 95% confidence intervals of cancer associated with meat intake.
Results: In themultivariable model there was a significant increase in the odds of cancers of the oral cavity and pharynx(OR=3.65, 95% CI: 2.21-6.01), esophagus (OR=3.36, 95% CI: 1.97-5.72), larynx (OR=2.91, 95% CI: 1.80-4.68),stomach (OR=2.19, 95% CI: 1.31-3.65), colorectum (OR=3.83, 95% CI: 2.37-6.20), lung (OR=2.17, 95% CI:1.52-3.10), breast (OR=1.97, 95% CI: 1.04-3.75), prostate (OR=1.87, 95% CI: 1.08-3.21), bladder (OR=2.11,95% CI: 1.20-3.72) and kidney (OR=2.72, 95% CI: 1.22-6.07) with high intake of red meat and similar findingswere found for total meat. In addition, intake of beef and lamb were also associated with increased risk ofseveral cancer sites. High intake of processed meat was associated with increased risk of cancers of the esophagus(OR=1.63, 95% CI: 1.08-2.47), larynx (OR=1.84, 95% CI: 1.21-2.78), stomach (OR=1.62, 95% CI: 1.07-2.44),colorectum (OR=2.15, 95% CI: 1.49-3.11), lung (OR=1.70, 95% CI: 1.28-2.25) and breast (OR=1.53, 95% CI:1.01-2.30).
Conclusion: Our results confirm earlier findings of increased risk of digestive tract cancers, butsuggest that meat consumption also increases the risk of several other cancers.
Date Issued
2009-03-01
Date Acceptance
2009-03-01
Citation
Asian Pacific Journal of Cancer Prevention, 2009, 10 (3), pp.429-436
ISSN
1513-7368
Publisher
West Asia Organization for Cancer Prevention
Start Page
429
End Page
436
Journal / Book Title
Asian Pacific Journal of Cancer Prevention
Volume
10
Issue
3
Copyright Statement
Asia Pacific Journal of Cancer Prevention is under the terms of the Creative Commons Attribution License. This permits anyone to copy, distribute, transmit, and adapt the published work, provided the original work and source are appropriately cited.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/19640186
Subjects
BLADDER-CANCER
BREAST-CANCER
cancer
COLORECTAL-CANCER
Diet
epidemiology
HETEROCYCLIC AMINES
LARYNGEAL-CANCER
Life Sciences & Biomedicine
meat
Oncology
PROCESSED MEAT
PROSTATE-CANCER
RED MEAT
RENAL-CELL CANCER
Science & Technology
UPPER AERODIGESTIVE TRACT
Publication Status
Published
Coverage Spatial
Thailand