Will oral food challenges still be part of allergy care in 10 years' time?
File(s)
Published version
Author(s)
Patel, Nandinee
Shreffler, Wayne G
Custovic, Adnan
Santos, Alexandra F
Type
Journal Article
Abstract
Oral food challenges (OFCs) are currently the definitive diagnostic procedure in food allergy. Their design has evolved over the decades to maximize safety, optimize convenience, and address several specific clinical questions. However, they are a resource-intensive investigation that carry a risk for severe allergic reaction in which fatal outcomes, although rare, have been reported. In this review, we explore the many roles that OFC fulfil in the clinical and research settings. We also discuss progress that has been made in developing alternative diagnostic tools and how far these have reached in offering a viable replacement to OFC in clinical practice. Finally, we discuss the ongoing importance of research OFC to improve the future diagnostic capabilities of novel diagnostic tools.
Date Issued
2023-04
Date Acceptance
2023-02-05
Citation
Journal of Allergy and Clinical Immunology: In Practice, 2023, 11 (4), pp.988-996
ISSN
2213-2198
Publisher
Elsevier
Start Page
988
End Page
996
Journal / Book Title
Journal of Allergy and Clinical Immunology: In Practice
Volume
11
Issue
4
Copyright Statement
© 2023 The Authors. Published by Elsevier Inc. on behalf of the American Academy
of Allergy, Asthma & Immunology. This is an open access article under the CC
BY license (http://creativecommons.org/licenses/by/4.0/).
of Allergy, Asthma & Immunology. This is an open access article under the CC
BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/36822320
PII: S2213-2198(23)00189-7
Subjects
Allergens
Food
Food Hypersensitivity
Humans
Skin Tests
Anaphylaxis
Basophil activation test
Double-blind placebo-controlled food challenge
Food allergy
IgE
Oral food challenge
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2023-10-22