HPV vaccination and cancer prevention
File(s)
Author(s)
Type
Journal Article
Abstract
Prophylactic vaccines have been found to be highly effective in preventing infection and pre-invasive and invasive cervical, vulvovaginal and anal disease caused by the vaccine types. HPV vaccines contain virus-like particles that lack the viral genome and produce high titres of neutralising antibodies. Although the vaccines are highly effective in preventing infections, they do not enhance clearance of existing infections. Vaccination programmes target prepubertal girls and boys prior to sexual debut as efficacy is highest in HPV naïve individuals. School-based programmes achieve higher coverage, although implementation is country specific. Vaccination of older women may offer some protection and acceleration of impact, although this may not be cost-effective. HPV-based screening will continue for vaccinated cohorts, although intervals may increase.
Date Issued
2020-05-01
Date Acceptance
2020-03-05
Citation
Best Practice and Research: Clinical Obstetrics and Gynaecology, 2020, 65, pp.109-124
ISSN
1521-6934
Publisher
Elsevier
Start Page
109
End Page
124
Journal / Book Title
Best Practice and Research: Clinical Obstetrics and Gynaecology
Volume
65
Copyright Statement
© 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Imperial College Healthcare NHS Trust
Identifier
https://www.sciencedirect.com/science/article/pii/S1521693420300365?via%3Dihub
Grant Number
RDD09 79560
Subjects
Science & Technology
Life Sciences & Biomedicine
Obstetrics & Gynecology
HPV
CIN
Cancer
Vaccine
Cost-effectiveness
HUMAN-PAPILLOMAVIRUS VACCINATION
CERVICAL INTRAEPITHELIAL NEOPLASIA
HPV-16/18 AS04-ADJUVANTED VACCINE
COSTA-RICA VACCINE
GENITAL WARTS
EFFICACY
WOMEN
INFECTION
IMMUNOGENICITY
SAFETY
CIN
Cancer
Cost-effectiveness
HPV
Vaccine
Aged
Cost-Benefit Analysis
Female
Humans
Male
Mass Screening
Papillomaviridae
Papillomavirus Infections
Papillomavirus Vaccines
Uterine Cervical Neoplasms
Vaccination
1114 Paediatrics and Reproductive Medicine
Obstetrics & Reproductive Medicine
Publication Status
Published
Date Publish Online
2020-03-05