Allergic endotypes and phenotypes of asthma
Author(s)
Akar-Ghibril, Nicole
Casale, Thomas
Custovic, Adnan
Phipatanakul, Wanda
Type
Journal Article
Abstract
Allergic asthma is defined as asthma associated with sensitization to aeroallergens, which leads to asthma symptoms and airway inflammation. Allergic asthma is the most common asthma phenotype. The onset of allergic asthma is most often in childhood and is usually accompanied by other comorbidities including atopic dermatitis and allergic rhinitis. It is often persistent although there is a wide variation in disease severity. It is a TH2-driven process. Biomarkers have been identified to distinguish patients with allergic asthma, particularly serum IgE levels, tests to indicate sensitization to aeroallergens such as specific IgE or skin prick test positivity, blood and sputum eosinophil levels, fraction of exhaled nitric oxide, and periostin. Treatments for allergic asthma include environmental control measures, allergen immunotherapy, and glucocorticoids. Biologics, targeting the TH2 pathway, have been shown to be effective in the treatment of allergic asthma.
Date Issued
2020-02-01
Date Acceptance
2019-11-16
Citation
Journal of Allergy and Clinical Immunology: In Practice, 2020, 8 (2), pp.429-440
ISSN
2213-2198
Publisher
Elsevier
Start Page
429
End Page
440
Journal / Book Title
Journal of Allergy and Clinical Immunology: In Practice
Volume
8
Issue
2
Copyright Statement
© 2019 American Academy of Allergy, Asthma & Immunology. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000512964500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Allergy
Immunology
Asthma
Allergic asthma
Allergic phenotype
Allergic endotypes
Biomarkers
EXHALED NITRIC-OXIDE
DOUBLE-BLIND
EOSINOPHILIC ASTHMA
MONOCLONAL-ANTIBODY
PERSISTENT ASTHMA
INHALED CORTICOSTEROIDS
INTERNATIONAL CONSENSUS
AIRWAY INFLAMMATION
NONALLERGIC ASTHMA
IMMUNOGLOBULIN-E
Publication Status
Published
Date Publish Online
2020-02-06